Guy Brusselle received his medical degree (M.D.) at Ghent University in 1990. Investigating the functional role of cytokines interleukin-4 (IL-4) and interleukin-5 (IL-5) in allergic asthma, he obtained his Ph.D. in 1997.

As a respiratory physician with a keen clinical and scientific interest in asthma, severe asthma and COPD, he joined the Ghent University Hospital in 2002.

Since 2008, he is professor of medicine at Ghent University, teaching “Methodology of Scientific Research and Study design” to medical students and pharmaceutical sciences students. Since 2021 he teaches the course “Respiratory Medicine” to master medical students at the Faculty of Medicine.

Since 2013, he is professor at the Departments of Epidemiology and Respiratory Medicine at Erasmus Medical Center Rotterdam in the Netherlands, where he is the Principal Investigator for Respiratory Diseases within the Rotterdam Study, a large prospective population-based cohort study.

Currently, he is head of the Laboratory for Translational Research of Obstructive Pulmonary Diseases at Ghent University.

From 2012 to 2015, he has served the European Respiratory Society (ERS) as Guidelines Director. From 2016 till 2019, he has been the chair of the ERS Science Council.

Since September 2017, he is member of the Scientific Committee of the Global Initiative for Asthma (GINA). Since September 2025, he is the Chair of the Board of Directors of GINA.